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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '0f250527bde20cb80823eb38cffd8c9888cd5e4cbce564899d8398a2c3a68fa2' 
  AND token = 'qY9hNiQOeP3CZdCirm+bmyTU5cGVqtCkXAoY9NZkOo4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}