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SELECT 
  1 
FROM 
  cscart_aprilec_print_temp_designs 
WHERE 
  session_id = 'PZD2-YLNY-L5YE-ZT86-GSKG-GYYM-V4W9-R2TE' 
  AND product_id = 165 
  AND expires_at > 1777640644 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}