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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '1b18200ec7c90cbbc01cd5b3b312afb441c606cdb1e1b20e18f51a88bade49a9' 
  AND token = 'IYZP0TFCb084Zd2ggBcnjAVWpwQzPQLY0ZC9v8Mah/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}