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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '7378fb86a25f6cf6d79553c207f791fa33a0063b375c11a43af9b94cc128f50b' 
  AND token = 'APPtfDEwzXNaM9qLMS+6Tx77ZjNcEJcmimH25DansTM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}