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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '5a220210a8cfbf5671e57e7b6525daa00d2342ff3bce1ab535c3760a5e564286' 
  AND token = 'RNX5/D9oHoM8imwnw9PDK2hpcyhDMmfSPru5h7N8S+U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}