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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'ea48850a59a5a08ee4c4ed0d3862e3a95ea0c821bf585402602b782822edc183' 
  AND token = 'GZGfyjfM4nDJzeGvW1TsO90MhoccGVjFn0lO8BR55X0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}