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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '78287a14e0d6c037627256f00140c2587886a11a5f5b2d8b98990fa3052667f9' 
  AND token = 'VWHIM9UX77v7tdCImVsRqIj6/Zje9wSGy8NC9Q7IPkw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}