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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'f000afeab455322f22625c75906da8a280e2b0c431feee1679d4120447ee938b' 
  AND token = '5Rg60XJpmyJ4BNsdl+8YCfbAYvNvdBnFAbJfAhuc/CM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}