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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '9e21e1974074ccbb61186f83934a4c437728e795194fcee07b3375a596527108' 
  AND token = 'Ma28f2P3Wpl7Hd6uAPiBKcitn4TIswUQYm+DeX2A+ao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}