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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '2f429929a79dc18167adfbee4f3aa7259e564e14aea03b53bab06314ad555508' 
  AND token = 'bxzbioOVozM+4c6Sm21JMv4v1YYOA/CL88qpAUkdLuM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}