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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '641ef2ee5453720d9c4e7fbf1494526ba23a505fd21f2180bdff7bb556e873a0' 
  AND token = '21+oY58BlCpQ03riRB3haWGGo5nv5S9vcrzU70m6X0I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}