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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'af6d4aee5376ed07a6a7010219c85d50e4f428ae0e90016b3273fcf8df58a259' 
  AND token = 'oHkFqE/nw44DCfUhyF1MQxo/yo2OsWVmSa+SYBUm1Wo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}