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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '25fd7f8357cfaef24c62f256c394ce67e1e21dcf2363e30c5e328727a3c99177' 
  AND token = 'S6wQmu4mTYZMo5DZPDyEgNXKFhnlo1WBn4EGEYVnio4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}