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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '4eab04d15cc428bbecd62850804096cbc9c3ac226c423772ec2289840da837b0' 
  AND token = 'nLadCNwJwzchOZbiHiZ76R5D4GXCjfapcqaaBkpVGhw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}