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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '1535d8138dc1339b40028d23b8da53a4a2cfdd9ae78c7a2a1ed391198584df64' 
  AND token = 'Xfm7gx0GRnj2KewWv+CmQgMm+DRL7XmmSddMI5AbG2w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}