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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '6d378042a8012a5f5c43a244fa825914e181e64e63e3036b04b04e66aa46375a' 
  AND token = '1tzGkK9Zv0EWSi2kVNcYINFp9lCWwIToR4wGOjg/xYA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}