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SELECT 
  1 
FROM 
  cscart_aprilec_print_temp_designs 
WHERE 
  session_id = 'U3X4-0B6M-8848-SK51-2O4J-LI7O-6BG2-12V4' 
  AND product_id = 200 
  AND expires_at > 1777138402 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}