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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'a800c153813d9eebc603678b504ae7e75364f44b88c27c1548affad69a82b160' 
  AND token = 'I09GtRDv+O2Ot4zFy9RtDUx7RmFAWf7SlE8BlKTbvuM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}