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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '44a8fafb4d505fc67cfa4d593d047c21293759052e16cdff574622e9a3d1e2d4' 
  AND token = 'aj+0oZyk3tRWf/yGo4uQjMsnjkZIRlnAiaSsZx6sdZI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}