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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '8278c73b141b1dba2272b4c936163ffbf6921ca1212fc67904688709a53d8e44' 
  AND token = 'R3eL50Zj3QmVR/FOVRKbQdXeoyxtbgloi/BSXyFsii4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}