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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'aaa2722de1bc484c001402a8be2b370e135452d9e6007d032e62790c5b35cf06' 
  AND token = 'De/Kx05AsMwsnOtHCgk8Lwuq/+EsuLmHErBOOkZ2ptU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}