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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'ec57f622d84e1cdc49c2c89450f7621690eee3ce401644c067f8af6d131c61c7' 
  AND token = 'wEmyHCC271nZcoZVcjQLzmZn2Cd/aC3H4MG0mgD8TR0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}