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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '281df4d6d27b24e2251951d20561e81cc0701cf20e2ac05ff81231111cea07b1' 
  AND token = 'qbIrZjeuytNiG4V6IoRWfrCUVngUuKD4ka68T2GeN0k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}