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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '726e6306b8dea3290a28ade8a067e9f2b41a4babc962e4585f3399aad0e9ff45' 
  AND token = 'XTU08lbjb/SKImgTm5t+rv5HQaSMpNn128VrSGSxvvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}