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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '10e8a288931f32347e61752a7d91aa5d272e6560edcd2563b27652289b3d6004' 
  AND token = 'U7YOH5z4FPt54navA+wk3028zimNPA7k2AOb4qDPF+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}