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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '66281e6df1d794070f27b1efddff14f50b21385882efdc1ccf9e143c3ff52a40' 
  AND token = 'l1ys443pFsylp1EQqUBIKIHNn9geYmWkkHD1YqXEzZw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}