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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '72111dedaed98522bf2992ab1e4fbeb4a7c8a0df335badb38480e02a52d2a05c' 
  AND token = 'a+COdfviH2CeyUpkqkDkjywFRctChhUAu0nfnVTABKg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}