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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '80a39a91eaf61bac5534451e10c729a516354a39417ce48894a13e5d1c1633f2' 
  AND token = 'rB0z+fb3wYpyF8M1V6OlxDp0g8B0pkFLhHO+IsfydKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}