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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'e0016851584cda7824c94fb32dd702fd7d0fb0a892f28f06e4feda32c50f3dca' 
  AND token = 'Tdj7A+dDsMqzcq1GSS21BVdDAMFGZKQHQVQ6pMOCiog=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}