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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '25c9ea3a8eb906685177293cb227671f8d2e0f644e185e16ac2e701282178c9c' 
  AND token = 'MqKVtFWOpc1MhlCVNpGIhPcGI72fn3K/4i7AicPECxI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}