Sandbox

SELECT 
  1 
FROM 
  cscart_aprilec_print_temp_designs 
WHERE 
  session_id = 'R2EE-W2OZ-7KLQ-V00E-MB0M-P0T0-DTRE-N85Y' 
  AND product_id = 75 
  AND expires_at > 1777123908 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}