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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '157e2ca3a65d707fd01f44270e829f395180ba3aff2ce927f73736418452daa9' 
  AND token = 'GgE7XLf9BJ1n1/3o2XyEad6fIfwc6iLgJevg2509NBg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}